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160 PROCEEDINGS OF INTERNATIONAL SCIENTIFIC CONFERENCE ON APPLIED BIOTECHNOLOGYcarrageenan injection was considered to be equivalent to the control drug indomethacin at a dose of 10 mg/kgP. In the formalininduced paw edema model, the electrospun nanofibers at a dose of 2.0 mg exhibited topical anti-inflammatory activity at 2 and 3 hours after injection of formalin. The effect of the nanofibers was found to be equivalent to the positive control diclofenac diethylamine emulgel at 2 hours after formalin injection. The results suggested the application of electrospun nanofibers loaded with 15% EPMC in anti-inflammatory products for the treatment of inflammation-related diseases.Keywords: anti-inflammatory effect, paw edema model, formalin, carrageenan, electrospun nanofibers loaded with EPMC1. INTRODUCTIONInflammation is a natural and protective response of the body to injury, infection, or harmful stimuli. It is part of the immune system%u2019s way of protecting tissues and promoting healing. The process involves a complex interplay of immune cells, blood vessels, and molecular mediators. Inflammation is typically characterized by four classic signs: redness, heat, swelling, and pain. These occur due to increased blood flow to the affected area, accumulation of fluid, and the release of inflammatory mediators [1, 2]. Anti-inflammatory agents are substances that help reduce inflammation in the body. They work by inhibiting the inflammatory response, which can alleviate symptoms such as pain, swelling, and redness associated with various conditions. Anti-inflammatory agents are important in managing various conditions, including arthritis, inflammatory bowel disease, allergies, and chronic pain [3, 4].