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IN VIVO ANTI-INFLAMMATORY ACTIVITY OF ELECTROSPUN NANOFIBERS LOADED WITH ETHYL-P-METHOXYCINNAMATEDo Thi Dinh1,2, Ngo Thi Phuong3, Do Thi Thao4, Nguyen Thai An1, Do Thi Thanh Huyen3, Le Minh Ha3,5*Abstract: In this study, electrospun nanofibers CS/PLA/PEG loaded with 15% EPMC (Ethyl-p methoxycinnamate) were investigated for their topical and oral anti-inflammatory activity in the formalin and carrageenan-induced mouse paw edema models. The results showed that electrospun nanofibers CS/PLA/PEG loaded with 15% EPMC at a dose of 200 mg/kgP exhibited oral antiinflammatory activity in the carrageenan-induced paw edema model at 5, 6, and 7 hours after injection of carrageenan. The anti-inflammatory effect of the nanofibers at 6, 7 hours after 1 Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi 100000, Vietnam2 Hai Duong Central College of Pharmacy, 324 Nguyen Luong Bang, Thanh Binh, Hai Duong 170000, Vietnam.3 Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18-Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, Vietnam4 Institute of Biotechnology, Vietnam Academy of Science and Technology (VAST), 18-Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, Vietnam5 Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18-Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, Vietnam* Correspondence: halm2vn@gmail.com; leminhha.inpc@gmail.com