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62 PROCEEDINGS OF INTERNATIONAL SCIENTIFIC CONFERENCE ON APPLIED BIOTECHNOLOGYin mice [9], CXCL12-induced invasion of breast and pancreatic tumor cells [10], apoptosis in liver cancer [11], suppress phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells and Epstein-Barr Virus activation [12-13]. Previous studies on the chemical composition of Z. zerumbet have revealed various bioactive compounds such as: zerumbone, borneol, %u03b1-pinene, %u03b2-pinene, camphor, linalool, limonene, %u03b1-curcumene, %u03b1-humulene, humulene monoxide, humulene dioxide, %u03b2-caryophyllene, camphene, cineole [14] and new sesquiterpenoids found in the essential oil of Indian Z. zerumbet rhizomes such as humulene epoxide I, humulene epoxide II, humulene epoxide III, humulenol I, humulenol II, and caryophyllene oxide [14-16]. Additionally, some new compounds have been identified from the essential oil of Z. zerumbetincluding cis-nerolidol, %u03b1-phellandrene, terpinolene, p-cymene, caryophyllene oxide, %u03b4-cardinene, fenchone, and bornyl acetate [17]. Phenolic compounds and glycosides have also been found, including zerumbone, 3-O-methyl kaempferol, kaempferol-3-O-(2,4-di-O-acetyl-%u03b1-L-rhamnopyranoside), and kaempferol-3-O-(3,4-di-O-acetyl-%u03b1-L-rhamnopyranoside) from Z. zerumbet rhizomes [18]. Among the bioactive compounds isolated from Z. zerumbet, zerumbone is the only compound that has been studied extensively. Zerumbone revealed in vivoantinociceptive [19] and anti-inflammatory [20-23] activities as well as exhibited antiproliferative [19] and antiplatelet aggregation activities [24].In our effort to find out plants with potential activity as antidiabetic agent, Z. zerumbet is a commonly known plant that contains many bioactive compounds capable of inhibiting %u03b1-glucosidase, making it a subject of growing research interest. Here in, we describe the study on Z. zerumbet collected in