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SECTION I: MOLECULAR GENETIC ENGINEERING AND BIOCHEMICAL TECHNOLOGY 61than that of acarbose (IC50 214.1 %u00b5M). The research demonstrated %u03b1-glucosidase inhibitory activity of the Zingiber zerumbet Linn rhizome as a potential antidiabetic agent.Keywords: Zingiber zerumbet, chloroform extract, %u03b1-glucosidase, vanillic acid, naringenin1. INTRODUCTIONZingiber zerumbet Linn Smith (Z. zerumbet), a member of the family Zingiberaceae, is widely cultivated throughout the tropical areas including Southeast Asia, Korea, India, Thailand, Bangladesh, etc., due to its potential medicinal properties [1-3]. The plant is perennial, grows to about 1-1.3 meters tall with short stems which are usually be replaced by pseudostems formed by leaf sheaths. Its rhizomes have been regularly used as food flavouring and appetizer in many countries%u2019 cuisines while rhizomes extracts have been used in traditional medicine as a cure for swelling, loss of appetite, lumbago, diabetes, inflammation, chest pains, rheumatic pains, bronchitis, dyspepsia and sore throat [4-7].In traditional Vietnamese medicine, Z. zerumbet is characterized by its bitter taste, neutral properties, and spicy flavor. It is valued for its ability to expel wind and cold, alleviate pain, and improve blood circulation, making it a common choice for remedies aimed at stimulating, toning, and detoxifying the body. Z. zerumbet is also used to treat ailments such as dizziness, nausea, fainting, and windstroke. It is particularly recognized for its detoxifying effects, postnatal recovery benefits, and its role in enhancing digestion [8].From the pharmacological point of view, Z. zerumbethas been reported to inhibit colon and lung carcinogenesis