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                                    SECTION II. APPLIED BIOTECHNOLOGY IN THE PHARMACEUTICAL INDUSTRY... 425The data in the tables above shows that all the indicators that make up productivity increased from formula 1 to formula 4, specifically as follows:For the experiment on green mustards: The actual yield in formula 2 increased 2.57 times compared to the control formula and in formulas 3 and 4 increased by 4.54 - 4.57 times compared to the control formula. For the experiment on water spinach: The actual yield in formula 2 increased 2.60 times compared to the control formula and in formulas 3 and 4 increased by 3.40 - 3.46 times compared to the control formula. For the experiment on tomato: The actual yield in formula 2 increased 6.57 times compared to the control formula and in formulas 3 and 4 increased by 17.4 - 17.7 times compared to the control formula.Accordingly, the best results are shown in formulas 3 and 4. Although there is a small difference in yield between formulas 3 and 4, statistically, the difference is not significant, which proves that the amount of fertilizer used with the ratio of formula 3 (1:1 between sea sand and organic microbial fertilizer) is the most effective, both ensuring the yield for crops and saving the amount of fertilizer used. 4. DISCUSSIONFrom the research results presented above, it can be seen that coastal sand soil is nutrient-poor and has chemical and physical properties that are not suitable for vegetable cultivation. This has also been pointed out in some previously published works [1,2,3]. To improve sandy soil, there are many methods implemented, including the use of organic fertilizer derived from agricultural byproducts [1,2]. This study utilizes rice straw, a plentiful byproduct generated after each rice harvest season, as a source of organic fertilizer. The organic fertilizer product derived from 
                                
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