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SECTION II. APPLIED BIOTECHNOLOGY IN THE PHARMACEUTICAL INDUSTRY... 4274 do not have significant differences in meaning, so formula 3 will be the most optimal formula, ensuring both productivity and saving the amount of fertilizer used. Previous studies on mixing sand with organic materials also showed promising results, specifically when mixed with biochar, the above-ground biomass of crops increased by over 60%, adding other organic materials, the biomass increased by over 48% [2]. Although using straw-based microbial fertilizer to mix with sand in this study resulted in superior crop yields, there are currently not many such publications. This can be considered a new result, adding a biological solution for sustainable agricultural development on coastal sand. 5. CONCLUSIONSThe sea sand in Truong Sa has poor nutritional content, making it unsuitable for vegetable growth. A solution involving organic fertilizer produced from rice straw with added functional microorganisms to boost crop productivity is a sustainable and environmentally friendly approach that contributes to on-site cultivation, meeting the demand for green vegetables on the island. Research indicates that the produced organic fertilizer meets the fertilizer standards outlined in the National Technical Regulation on Fertilizer Quality - QCVN 01-189:2019/BNNPTNT. Combining organic fertilizer and microbial preparations in a 20% ratio resulted in products meeting the quality requirements for microbial fertilizer according to the standard. Mixing sand and microbial organic fertilizer in different ratios of 2:1, 1:1, and 1:2 all led to increased vegetable and tomato yields compared to the control group (grown only on sand without added microbial organic fertilizer). Specifically, vegetable biomass increased by over 2.57 times in formula 2 and over 3.40 times in formula 3 and formula 4. Similar experiments with tomato plants yielded