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SECTION II. APPLIED BIOTECHNOLOGY IN THE PHARMACEUTICAL INDUSTRY... 3952.42 Idl/100 g. Notably, the density of beneficial microorganisms, nitrogen-fixing bacteria, phosphate-solubilizing bacteria, and cellulose-decomposing microorganisms all increase after four months, with respective rises from 1.92 x 106, 2.64 x 105, 4.48 x 105, 3.55 x 105 to 6.86 x 106, 1.45 x 106, 2.04 x 106 and 1,71x106. The profit is 54,870,000 VND, achieving a return on investment of 1.61 times.Keywords: Peanut plant, microbial formulations, poor soil, soil improvement. 1. INTRODUCTIONPeanuts have long been recognized as a key crop in Quang Tri Province, serving as a primary income source for numerous farmers. However, excessive use of fertilizers and chemical pesticides has led to the accumulation of harmful substances in the environment, leaving residues on agricultural products and in the soil. This contamination poses direct health risks to both producers and consumers and contributes to the ongoing degradation of arable land. Thus, advancing research and applications of microbial products containing beneficial microorganisms is essential, as these can enhance soil quality, support healthy plant growth, reduce pests and diseases, and increase crop yields. Integrating crop and soil management with biotechnological products and methods underscores the critical role of soil biological processes. The addition of microbial strains and organic matter mixtures into the soil fosters the establishment of beneficial microbial communities, thereby aiding in soil remediation, enhancing soil health, improving crop performance, and reducing environmental impact [1]. Consequently, the utilization of microbial products to process organic waste and agricultural by-products for fertilizers and soil improvement, alongside pest control and yield enhancement,