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306 PROCEEDINGS OF INTERNATIONAL SCIENTIFIC CONFERENCE ON APPLIED BIOTECHNOLOGYDPPH radical-scavenging activity was observed on pomegranate peel medium for P. pulmonarius BV13 and X. longipes BV1. Thus, Basidiomycota strains showed a remarkable natural capacity to produce antioxidants, such as flavonoids and DPPH radical-scavenging activity, and to release flavonoids from pomegranate peel. Notably, Basidiomycete fungi displayed significantly higher intrinsic flavonoid production than ascomycete fungi.Keywords: Ascomycetes, Basidiomycetes, Laccase, Catalase, Pomegranate peel, Solid-state fermentation.1. INTRODUCTIONThe food industry generates large amounts of inedible agricultural waste, such as pomegranate peels, or orange peels, etc. which are rich in nutrients like polysaccharides, fibers, and proteins. In recent estimates [1]. Pomegranate peels are rich in antioxidants, showing significant potential for reuse into value added products through biotechnological conversion. The human body needs to be regularly supplemented with natural antioxidants from plants or microorganisms [2]. Food waste treatment can provide a valuable source of natural antioxidants and bioactive compounds, especially polyphenols. Polyphenols have many effects such as anti-cancer, antibacterial, antioxidant and immune stimulation, and help reduce the risk of cardiovascular diseases, diabetes, rheumatoid arthritis, etc [3]. In the food industry, the fruit processing process generates solid waste (e.g. fruit peels), which contains components such as soluble sugars, fiber, minerals, vitamins and low lignin content. This special component contains many nutrients for the growth of many beneficial microorganisms, and they can be transformed into value-added products such as antioxidants, bioactives and antibiotics [4]. Fungi from the Basidiomycetes and