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SECTION I: MOLECULAR GENETIC ENGINEERING AND BIOCHEMICAL TECHNOLOGY 229(NMR) spectroscopy in conjunction with comparisons to spectral data from the literature. The compound (7S,8R,8%u2019R)-5%u2019-methoxy isolariciresinol (5) is reported here for the first time to be isolated from the genus Persea. This is the first study to publish on the chemical composition of Vietnamese avocado leaves.Keywords: Persea americana, luteolin, luteolin-7-O-glucoside, (7S,8R,8%u2019R)-5%u2019-methoxy isolariciresinol, (6S,9R)-roseoside, rutin1. INTRODUCTIONAvocado, scientific name Persea americana Mill., belongs to the Lauraceae family. It is a woody plant that can grow up to 15 meters tall; its leaves are lanceolate, elongated, or oval, measuring 6 to 25 cm in length and 3.5 to 15 cm in width, with a short acute angle at the base and a pointed or rounded tip; the flower clusters are dense cymes; the flowers are small, greenish or yellow; the calyx is finely hairy; the fruit is a large berry, fleshy, pear-shaped, oval or spherical, green or purple when ripe; the flesh is soft, greenish-yellow, containing a large seed with a fleshy cotyledon. The avocado tree is distributed in the tropical regions of the Americas, Africa and Israel. In Vietnam, it is widely cultivated in the provinces of Lam Dong, Dak Nong, Gia Lai and some other provinces in the Tay Nguyen region of Vietnam. The avocado is not only known as a fruit tree but also as a valuable medicinal plant with good therapeutic properties. In traditional medicine, avocado fruit is used to support recovery for patients who have just recovered from illness, those who work excessively, individuals with high acidity in urine and those suffering from stomach ailments. Additionally, avocado leaves are used in folk remedies, either fresh or dried, boiled in water to treat digestive disorders, stomach issues, diabetes, and high cholesterol, as well as to aid memory enhancement [1].