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SECTION I: MOLECULAR GENETIC ENGINEERING AND BIOCHEMICAL TECHNOLOGY 103The early finding on ADMET properties has resulted in a decline in the attrition rates of therapeutic drugs during clinical development. The compounds that have fit physicochemical properties, and low toxicity levels are highly concerned. The molecular properties such as octanol-water partition coefficient (LogP), molecular weight, hydrogen bond acceptors (HBA), hydrogen bond donors (HBD), and molar refractivity (MR) are presented in Table 4. All investigated compounds adhere to Lipinski%u2019s rules, except for streptomycin, which violates three rules. The LogP values of %u03b1-pinene, %u03b2-pinene, and myrtenyl acetate are 2.999, 2.999, and 2.542, respectively, reaching one of Lipinski%u2019s criteria for LogP (<5). Furthermore, myrtenyl acetate, with a lower molecular weight than the reference compound streptomycin and 2 hydrogen bond acceptors, does not violate Lipinski%u2019s rules. The prediction of LD50 values and toxicity assessment on a scale of 1 to 6 (ranging from highly toxic to safe) for the compounds using the ProTox web server is presented in Table 4. The prediction results indicate that the investigated compounds, %u03b1-pinene, %u03b2-pinene, and myrtenyl acetate, exhibit a toxicity level of 5, with LD50 values of 3700, 4700, and 2600 mg/kg, respectively. This suggests that these compounds have low toxicity and are safe for oral administration. The reference compound, streptomycin, exhibits a low LD50 value, indicating high toxicity. In general, the main components, %u03b1-pinene, %u03b2-pinene, and myrtenyl acetate, illustrate good compatibility as they comply with Lipinski%u2019s rule of 5, indicating their potential to exhibit drug-like characteristics through oral administration [17] and their low toxicity. Therefore, these compounds are promising candidates that require further research and development for future applications.