Page 23 - Demo

SECTION I: MOLECULAR GENETIC ENGINEERING AND BIOCHEMICAL TECHNOLOGY 27Figure 3. Structure of ecumicin3.3. Effect of ecumicin on the replicating M tb and drug-resistant M.tb Ecumicin has an in vitro anti-M. tuberculosis activity profile comparable to or superior to that of the current first-line antiTB drugs. Activities were also maintained against nine clinical strains, including MDR and XDR M. tuberculosis isolates, and against M. tuberculosis clinical isolates representing the six major global clades (Table 1). TABLE 1: MICs of ecumicin and anti-TB drugs versus M. tuberculosis