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SECTION I: MOLECULAR GENETIC ENGINEERING AND BIOCHEMICAL TECHNOLOGY 209strain, thereby isolating compounds with high biological activity, in order to create valuable natural products in medicine, helping to prevent and treat cancer, anti-inflammatory, anti-infection.Funding: This work was financially supported by the Ministry of Science and Technology under grant No %u0110T%u0110L.CN-114/21.Conflicts of Interest: The authors declare no conflict of interest. REFERENCES1. Rocha-Martin, J.; Harrington, C.; Dobson, A.D.W. and O%u2019Gara, F. Emerging Strategies and Integrated Systems Microbiology Technologies for Biodiscovery of Marine Bioactive Compounds. Mar. Drugs, 2014, 12: 3516-3559. doi:10.3390/md12063516.2. Giovanni, S.J; Tripp, H.J; Givan, S.; Podar, M.;, Vergin, K.L.; Baptista, D.; Bibbs, L.; Eads, J.; Richardson, T.H.; Noordewier, M.; Rapp%u00e9, M.S.; Short, J.M.; Carrington, J.C.; Mathur, E.J. Genome streamlining in a cosmopolitan oceanic bacterium. Science, 2005, 309: 1242-1245.3. Davies-Vollum, K.S.; Zhang, Z.; Agyekumhene, A. Impacts of lagoon opening and implications for coastal management: case study from Muni-Pomadze lagoon, Ghana. Journal of Coastal Conservation, 2019, 23: 293-301.4. Quero, G.M.; Perini, L.; Pesole, G.; Manzari, C.; Lionetti, C.; Bastianini, M.; Marini, M.; Luna, G.M. Seasonal rather than spatial variability drives planktonic and benthic bacterial diversity in a microtidal lagoon and the adjacent open sea. Mol. Ecol., 2017, 26(21): 5961-5973.5. Bolorunduro, D.O.F.; Adeleye, I.A.; Akinleye, M.O.; Wang, P.G. Anticancer potential of metabolic compounds from marine actinomycetes isolated from Lagos Lagoon sediment. Journal of Pharmaceutical Analysis, 2019, 9: 201e208.