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184 PROCEEDINGS OF INTERNATIONAL SCIENTIFIC CONFERENCE ON APPLIED BIOTECHNOLOGYThese are the initial research results for the nanofibers CS/PLA/PEG loaded with 12% capsaicin. Further in-depth studies on other activities in vitro and in vivo need to be continued to provide scientific data for the application of the nanofibers CS/PLA/PEG loaded capsaicin in biomedical field in the future.5. CONCLUSIONSIn the current paper, we fabricated the nanofibers loaded with 12% of capsaicin (w/w) from biodegradable, biocompatible, non-toxic, and environmentally friendly polymers including CS, PEG, PLA, and a natural bioactive compound capsaicin by electrospinning method. The nanofibers were investigated for their morphological characteristics, chemical, mechanical, wettability and antibacterial properties. The produced nanofibers were uniform, smoothly with the average fiber diameter of about 269%u00b154 nm. The nanofibers CS/PLA/PEG loaded with 12% capsaicin revealed antibacterial property against four strains Escherichia coli, Staphylococcus aureus subsp. Aureus, Aspergillus niger, and Bacillus subtillis subsp. spizizenii with MIC value from 100 %u2013 400 %u00b5g/mL. However, the nanofibers did not show antibacterial activity against Pseudomonas aeruginosa, Fusarium oxysporum, Candida albicans, and Saccharomyces cerevisiae.Funding: This work was performed under the financial support of Vietnam-Czech Republic joint research project (Grant No. N%u0110T/CZ/23/07).Conflicts of Interest: The authors declare no conflict of interest.REFERENCES1. Sahibzada, M.U.K.; Sadiq, A.; Faidah, H.S.; et al. Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity. Drug Des Devel Ther 2018, 303-312.