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182 PROCEEDINGS OF INTERNATIONAL SCIENTIFIC CONFERENCE ON APPLIED BIOTECHNOLOGYsolubility in water, sensitivity to light, temperature, capsaicin%u2019s application has some limitations [23]. The encapsulation of capsaicin has attracted more attention from many researchers. Several nanoscale systems carrying capsaicin have been reported such as Capsaicin-incorporated zein electrospun nanofibers [23], honey/Chitosan Nanofibers Loaded with Capsaicin [24], capsaicin-loaded chitosan nanocapsules [25], etc. In our current study, for the first time, a polymer matrix system CS, PLA, PEG carrying capsaicin was fabricated. The CS component has anti-inflammatory, antibacterial activity, and is a polymer commonly used as a drug carrier [26]. PLA is a biodegradable and biocompatible polymer with high mechanical strength, making it easy to fabricate nanofibers by electrospinning method [8]. PEG is a hydrophilic polymer and the presence of PEG may help to enhance drug release in vivo [12]. The nanofibers made of polymers CS, PLA, and PEG loaded with 12% of capsaicin (w/w) were produce by electrospinning method. The selected content of capsaicin in the nanofibers was the highest content at which the electrospun nanofibers formation process went smoothly. At the content of capsaicin more than 12%, the produced nanofibers had beads and the fiber formation process was interrupted because the injector of electrospinning machine was clogged.The nanofibers have been evaluated for properties including morphological, chemical, mechanical, wettability and antibacterial properties. The surface of the nanofibers CS/PLA/PEG loaded with 12% capsaicin was smooth, uniform, without any beads with the average fiber diameter of 269%u00b154 nm, and about 85% of fibers population had a diameter between 200 %u2013 350 nm. The FT-IR spectrum of the nanofibers revealed three major peaks at 1750 (C=O) and 1181, 1082 cm%u22121 (C-O). This suggested the interaction between the components capsaicin,