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172 PROCEEDINGS OF INTERNATIONAL SCIENTIFIC CONFERENCE ON APPLIED BIOTECHNOLOGYmechanical properties and hydrophilicity of the nanofibers were also investigated. The results exhibited a tensile strength of 2.11 %u00b1 0.64 MPa, an elongation at break of 13.22 %u00b1 1.65%, and a Young%u2019s modulus of 95.49 %u00b1 4.94 MPa. The nanofibers were found to be hydrophilic with the contact angle of 73.7 %u00b1 1.5o. Capsaicin-loaded nanofibers exhibited significant antibacterial activity against four bacterial strains including Escherichia coli, Staphylococcus aureussubsp. Aureus, Bacillus subtillis subsp. Spizizenii, and Aspergillus niger. However, the nanofibers did not exhibit antibacterial activity against Pseudomonas aeruginosa, Fusarium oxysporum, Candida albicans, and Saccharomyces cerevisiae. This is the first time that electrospun CS/PLA/PEG loaded with 12% capsaicin nanofibers have been prepared and their characteristic and antibacterial property were reported. Keywords: Electrospun nanofibers, capsaicin, chitosan, polyethylene glycol, polylactic acid, antibacterial effect 1. INTRODUCTIONIn recent years, nanotechnology has become increasingly popular with a variety of applications across different fields, such as textiles, cosmetics, software technology, agriculture and medicine. Among these, nanotechnology in medicine or nanomedicine, is a relatively new and rapidly developing field that combines nanotechnology with biomedical and pharmaceutical sciences, including nanopharmaceuticals, nanoimaging agents and therapeutic diagnostics. At the nanoscale, the physical, chemical and biological properties of materials differ from those of materials at larger sizes. There have been many studies applying nanotechnology to create materials with new properties [1].