Page 262 - Demo

266 PROCEEDINGS OF INTERNATIONAL SCIENTIFIC CONFERENCE ON APPLIED BIOTECHNOLOGYfungal papilla of the tongue and jointly mediates the signaling of umami substances in the form of polymers. When stimulated by umami substances, umami substances directly bind to T1R1+T1R3. This activates PLC-%u03b22, producing DAG and IP3. IP3 binds to IP3R3 to release the stored Ca2+ in the cell. This activates the TRPM5 channel, and Na+ flows into the cell. Eventually, it prompts membrane depolarization and neurotransmitter release, making people perceive umami. Taste perception is influenced by taste receptors. The expression of taste receptors (proteins) is regulated by the taste gene network (Figure 1) [19]. J.M.Kim et al. discovered a new taste regulatory gene TAS1R1/TAS1R3 in the taste perception network of pigs using gene network technology. The up-regulated expression of this gene enhances the perception of umami in pigs [20].Figure 1. Taste gene regulatory network